User blog comment:GouenjiShuuya'123/Inazuma Eleven 3 announced for Europe!/@comment-85.168.125.203-20130215150119/@comment-4928091-20130215150422

Well thats a good question see with 3DS games like Mario Kart 7 you can verse other players on your friends list and over the world but with DS games and mainly Inazuma Eleven I don't know???

I think so but it depends on if in game your able to, but for other games like Pokemon its able to play against anyone on either DS or 3DS.